Extensive mucosal erosion and sloughing of tongue: a hitherto unknown complication of topical clotrimazole preparation.
نویسندگان
چکیده
Clotrimazole, a broad-spectrum imidazole antimycotic, is a widely-used prescription as well as an over-the-counter drug for treatment of mucosal (oral, vulvovaginal) candidiasis and dermatophytes. An extremely safe and well-tolerated drug, its safety profile has been well-explored in researches and trials. The commonest complaints are almost always non-serious-pruritus, rashes, paraesthesia (stinging/burning sensation) and erythema on topical applications, and nausea, vomiting, unpleasant taste sensation and elevated liver enzymes on oral preparations (troches). However, mucosal ulceration on topical clotrimazole preparation has not been reported in literature before. We present here the first documentation of extensive bilateral erosions and necrosis of tongue involving the mucosa, submucosa and musculature on application of one percent weight/volume clotrimazole mouth paint in a 27-year-old immunocompetent woman who presented with oral candidiasis.
منابع مشابه
Artemisia sieberi lotion 5% compared with Clotrimazole lotion in the treatment of Tinea versicolor
To determine the effect of Artemisia sieberi lotion in signs & symptoms of Tinea versicolor, a randomized, double - blind clinical trial was performed comparing topical application of Artemisia sieberi lotion with Clotrimazole topical lotion, twice daily for 2 week. 60 patients suffering from Tinea versicolor completed the study. 29 patients were treated with Artemisia sieberi lotion and 31 pat...
متن کاملArtemisia sieberi lotion 5% compared with Clotrimazole lotion in the treatment of Tinea versicolor
To determine the effect of Artemisia sieberi lotion in signs & symptoms of Tinea versicolor, a randomized, double - blind clinical trial was performed comparing topical application of Artemisia sieberi lotion with Clotrimazole topical lotion, twice daily for 2 week. 60 patients suffering from Tinea versicolor completed the study. 29 patients were treated with Artemisia sieberi lotion and 31 pat...
متن کاملمقایسهی اثربخشی نقرهی کلوئیدی موضعی با کلوتریمازول موضعی در درمان تینهآی سر و تینهآی بدن: کارآزمایی بالینی غیرتصادفی
Background and Aim: Dermatophytoses are the infections caused by the fungi that are capable to invade and multiply within keratinized tissues such as the skin, hair and nails. Topical azoles are considered the first-line treatment in dermatophytosis, but systemic therapy may also be required in some cases. Fungal skin infections have become more common in recent years, and injudicious use of co...
متن کاملPrevalence of Geographic Tongue and Its Relation with Food Allergy and Familial History in Patients Referred to Semnan Dental Faculty (2018–2019)
Background and Objectives: The cause of geographic tongue is unknown and a few studies have been carried out on the associations of this lesion with food allergy. The aim of this study was to assess the prevalence of geographic tongue and its associations with food allergy and familial history in the patients referred to the Oral and Maxillofacial Medicine Department of Semnan Dental School, Se...
متن کاملTopical sucralfate for erosive irritant diaper dermatitis.
We present the case of a 42-year-old woman with spina bifida and paraplegia who was referred to us because of chronic discomfort related to erosions and ulcerations of her perineal area, buttocks, and upper posterior thighs (Figure 1). Twenty years previously she had an ileal diversion and urostomy resulting in chronic urethral discharge and diarrhea for 5 years. She required a diaper constantl...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- JNMA; journal of the Nepal Medical Association
دوره 52 189 شماره
صفحات -
تاریخ انتشار 2013